Combining Photothermal Therapy with A NanohybridBased Drug Delivery Strategy for Slow-Released Doxorubicin: A Treatment for Hepatocellular Carcinoma
نویسندگان
چکیده
Background: Hepatocellular carcinoma (HCC) is the fifth most common malignancy in world. Surgical intervention remains primary treatment option for resectable liver cancer. However, low curative resection ratio, high metastatic and risk of recurrence make this less than ideal. Additionally, choice transplantation limited by availability donors. This literature review aimed to discuss combination strategy photothermal therapy nanohybrid-based chemotherapy delivery, which are expected address challenges HCC treatment. Methods: We conducted searches Pubmed, Scopus, ProQuest, Google Scholar using combined keywords such as “hepatocellular carcinoma”, “polyethylene glycol”, “doxorubicin”, “mesoporous silica”, “CuS”, “nanoparticle”, “photothermal therapy”. Based on assessment validity applicability aspects modified Oxford CEBM (Center Evidence-Based Management) OHAT (Office Health Assessment Translation) checklist tools preclinical studies, all selected studies fulfilled eligibility criteria. Results: Photothermal promotes necrosis apoptosis cells ‘heating’ cancer cells. Meanwhile, agent doxorubicin, with mesoporous silica nanohybrids encapsulated copper sulfate polyethylene glycol (PEG-DOX-MSN-CuS), enhances efficiency duration drug circulation blood, reduces clearance, minimizes retention reticuloendothelial system. By utilizing near-infrared light induction from therapy, doxorubicin can be slowly released, leading significantly improved effectiveness. In vitro have demonstrated that achieves over 90% cell death at a concentration 80 µg/mL, conjunction induction. The optimal release time was recored concise 20 minutes. Conclusions: Given numerous benefits associated strategies, PEG-DOX-MSN-CuS holds significant promising HCC.
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ژورنال
عنوان ژورنال: Indonesian Journal of Cancer
سال: 2023
ISSN: ['2355-6811']
DOI: https://doi.org/10.33371/ijoc.v17i2.964